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Research Publications

Alloimmune Thrombocytopenia

Rink BD, Gonik B, Chmait RH, O’Shaughnessy R. Maternal hemolysis after intravenous immunoglobulin treatment in fetal and neonatal alloimmune thrombocytopenia. Obstet Gynecol. 2013 Feb;121(2 Pt 2 Suppl 1):471-3.

Amniotic Bands

Assaf R, Llanes A, Chmait R. In utero release of constriction amniotic bands via blunt dissection. Fetal Pediatr Pathol. 2012 Feb;31(1):25-9.

Chorioangioma

Jones K, Tierney K, Grubbs BH, Pruetz JD, Detterich J, Chmait RH. Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction. Fetal Diagn Ther. 2012;31(3):191-5.

Congenital Cystic Adenomatoid Malformation

Lee FL, Said N, Grikscheit TC, Shin CE, Llanes A, Chmait RH. Treatment of congenital pulmonary airway malformation induced hydrops fetalis via percutaneous sclerotherapy. Fetal Diagn Ther. 2012;31(4):264-8.

Congenital Diaphragmatic Hernia

Quintero RA, Kontopoulos EV, Quintero LF, Landy DC, Gonzalez R, Chmait RH. The observed vs. expected lung-to-head ratio does not correct for the effect of gestational age on the lung-to-head ratio. J Matern Fetal Neonatal Med. 2013 Apr; 26(6):552-557.

Sosa CS, Bermudez C, Chmait RH, Kontopoulos E, Corboda Y, Guevara-Zuloaga F, Steffenson T, Quintero R. Intraluminal tracheal occlusion using a modified 8-mm Z-stent in a sheep model of left-sided congenital diaphragmatic hernia. J Matern Fetal Neonatal Med. 2012 Nov;25(11):2346-53.

Quintero RA, Quintero LF, Chmait R, Gomez Castro L, Korst LM, Fridman M, Kontopoulos EV. The quantitative lung index (QLI): a gestational age-independent sonographic predictor of fetal lung growth. Am J Obstet Gynecol. 2011 Dec;205(6)544.e1-8.

Fetal Anemia

Grubbs BH, Korst LM, Llanes A, Chmait RH. Middle cerebral artery Doppler and hemoglobin changes immediately following fetal transfusion. J Matern Fetal Neonatal Med. 2013 Jan;26(2):155-7.

Fetal Muscle Biopsy

Shanske S, Naini A, Chmait RH, Akman HO, Mansukhani M, Lu J, Hirano M, Dimauro S. Mutation in an mtDNA protein-coding gene: prenatal diagnosis aided by fetal muscle biopsy. J Child Neurol. 2013 Feb;28(2):264-8.

Iatrogenic Preterm Premature Rupture of Membrane

Pathak B, Khan A, Assaf SA, Miller DA, Chmait RH. Amniopatch as a treatment for rupture of membranes following laser surgery for twin-twin transfusion syndrome. Fetal Diagn Ther. 2010;27(3):134-7.

Lower Urinary Tract Obstruction

Quintero RA, Gomez Castro LA, Bermudez C, Chmait RH, Kontopoulos EV. In utero management of fetal lower urinary tract obstruction with a novel shunt: A landmark development in fetal therapy. J Matern Fetal Neonatal Med. 2010 Aug;23(8):806-12.

Spina Bifida

Pedreira DA, Zanon NC, de Sa RA, Acacio GL, Ogeda E, Balem TM, Chmait RH, Kontopoulos E, Quintero RA. Fetoscopic single-layer repair of open spina bifida using a cellulose patch: preliminary clinical experience. J Matern Fetal Neonatal Med. 2013 Dec 4. [Epub ahead of print]

Twin-Twin Transfusion Syndrome

Chmait RH, Kontopoulos EV, Quintero RA. Sequential Laser Surgery for Twin-Twin Transfusion Syndrome. Am J Perinatol. 2014 Jun 17.

Chon AH, Korst LM, Llanes A, Miller DA, Ouzounian JG, Chmait RH. Midtrimester isolated polyhydramnios in monochorionic diamniotic multiple gestations. Am J Obstet Gynecol. 2014 May 22.

Vanderbilt DL, Schrager SM, Llanes A, Hamilton A, Seri I, Chmait RH. Predictors of two-year cognitive performance after laser surgery for twin-twin transfusion syndrome. Am J Obstet Gynecol. 2014 Mar 26.

Chmait RH, Korst LM, Llanes A, Mullin P, Lee RH, Ouzounian JG. Perioperative characteristics associated with preterm birth in twin-twin transfusion syndrome treated by laser surgery. Am J Obstet Gynecol. 2013 Sep; 209(3):264.e1-8.

Chen K, Chmait RH, Vanderbilt D, Wu S, Randolph L. Chimerism in monochorionic dizygotic twins: case study and review. Am J Med Genet A. 2013 Jul; 161(7): 1817-24.

Vanderbilt DL, Schrager SM, Llanes A, Chmait RH. Prevalence and risk factors of cerebral lesions in neonates after laser surgery for twin-twin transfusion syndrome. Am J Obstet Gynecol. 2012 Oct;207(4):320.e1-6.

Patel S, Randolph LM, Benirschke K, Llanes A, Yedigarova L, Chmait RH. Prevalence of noncardiac structural anomalies in twin-twin transfusion syndrome. J Ultrasound Med. 2012 Apr;31(4):555-560.

Rossi AC, Vanderbilt D, Chmait RH. Neurodevelopmental outcomes after laser therapy for twin-twin transfusion syndrome: a systematic review and meta-analysis. Obstet Gynecol. 2011 Nov;118(5):1145-50.

Pruetz JD, Sklansky M, Detterich J, Korst LM, Llanes A, Chmait RH. Twin-twin transfusion syndrome treated with laser surgery: postnatal prevalence of congenital heart disease in surviving recipients and donors. Prenat Diagn. 2011 Oct;31(10):973-7.

Grubbs BH, Benirschke K, Korst LM, Llanes A, Yedigarova L, Chmait RH. Role of low placental share in twin-twin transfusion syndrome complicated by intrauterine growth restriction. Placenta. 2011 Aug;32(8):616-8.

Chmait RH, Kontopoulos EV, Korst LM, LLanes A, Petisco I, Quintero RA. Stage-based outcomes of 682 consecutive cases of twin-twin transfusion syndrome treated with laser surgery: the USFetus experience. Am J Obstet Gynecol. 2011 May;204(5):393.e106.

Aghajanian P, Assaf SA, Korst LM, Miller DA, Chmait RH. Fetal middle cerebral artery Doppler fluctuations after laser surgery for twin-twin transfusion syndrome. J Perinatol. 2011 May;31(5):368-72.

Assaf SA, Korst LM, Chmait RH. Normalization of amniotic fluid levels after fetoscopic laser surgery for twin-twin transfusion syndrome. J Ultrasound Med. 2010 Oct;29(10):1431-6.

Pathak B, Quintero R, Kontopoulos E, Assaf S, Miller D, Chmait RH. Postoperative middle cerebral artery peak systolic velocity changes confirm physiological principles of the sequential laser technique for twin-twin transfusion syndrome. Fetal Diagn Ther. 2010;28(3):140-4. [Editor’s Choice]

Chmait RH, Assaf SA, Benirschke K. Residual vascular communications in twin-twin transfusion syndrome treated with sequential laser surgery: frequency and clinical implications. Placenta. 2010 July;31(7):611-14.

Chmait RH, Kontopoulos E, Bornick PW, Maitino T, Quintero RA. Triplets with feto-fetal transfusion syndrome treated with laser ablation: The USFetus experience. J Maternal Fetal Neonatal Med. 2010 May;23(5):361-5.

Quintero RA, Chmait RH, Bornick PW, Kontopoulos EV. Trocar-assisted selective laser photocoagulation of communicating vessels: A technique for the laser treatment of patients with twin-twin transfusion syndrome with inaccessible anterior placentas. J Matern Fetal Neonatal Med. 2010 Apr;23(4):330-4.

Assaf SA, Khan A, Korst LM, Chmait RH. Fetal heart rate changes associated with sequential selective laser surgery for twin-twin transfusion syndrome. J Perinatol. 2010 Mar;30(3):188-91.

Chmait RH, Khan A, Benirschke K, Miller D, Korst LM, Goodwin TM. Perinatal survival following preferential sequential selective laser surgery for twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2010 Jan;23(1):10-6.

Pathak B, Benirschke K, Chmait RH. Umbilical artery hypoplasia in twin-twin transfusion syndrome complicated by discordant umbilical artery Doppler findings in the donor twin: a diagnostic dilemma. J Ultrasound Med. 2009 Aug;28(8):1107-10.

Pruetz JD, Chmait RH, Sklansky MS. Complete right heart flow reversal: pathognomonic recipient twin circular shunt in twin-twin transfusion syndrome. J Ultrasound Med. 2009 Aug;28(8):1101-6.

Chavira ER, Khan A, Korst LM, Miller D, Goodwin TM, Chmait RH. Are patients with twin-twin transfusion syndrome and a very short cervix candidates for laser surgery? J Ultrasound Med. 2009 May;28(5):633-9.

Vasa Previa

Johnston R, Shrivastava VK, Chmait RH. Term vaginal delivery following fetoscopic laser photocoagulation of type II vasa previa. Fetal Diagn Ther. 2014;35(1):62-4.

Chmait RH, Chavira E, Kontopoulos EV, Quintero RA. Third Trimester fetoscopic laser ablation of type II vasa previa. J Matern Fetal Neonatal Med. 2010 May;23(5):459-62.


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Cole Landry's Story: 2009

The Landry family.

Dr. Ramen Chmait performed the the fourth successful procedure worldwide to shrink a congenital cystic adenomatiod malformation (CCAM), a mass of abnormal lung tissue, and release the pressure on Cole's heart thereby giving him a chance at surviving. Today Cole is a happy, smiling boy.

learn more about acardiac twins

Twin-Twin Transfusion Syndrome: 2007

LA Fetal Therapy is pioneering a new treatment for twin-twin transfusion syndrome, also known as TTTS, using laser energy to seal off the blood vessels that shunt blood between two fetuses that share the same placenta.

learn more about acardiac twins

Lower Urinary Tract Obstruction: 2008

Fetal lower urinary tract obstruction (LUTO) is a rare condition that is caused by a blockage of fetal urination. Because the baby cannot empty the bladder, the baby’s bladder subsequently becomes very large and distended. Learn more about what LA Fetal Therapy is doing to correct this fetal condition in utero.

learn more about acardiac twins